The Mass Spectrometry and Analytical Proteomics Laboratory (MSL/APL). Director Todd D. Williams, is a research resource with a primary mission to provide collaboration and service in chemical analysis by mass spectrometry and to educate investigators on the uses of mass spectrometry as a research tool.
The lab operates nine instruments in two locations, Malott Hall and the Structural Biology Center. Access to the resource varies from “walk up and run your own sample” to the lab’s supervision of graduate student or postdoctoral associates in the facility working on extended projects. Instrumentation covers most of the common ionization methods and data acquisition in high resolution and/or tandem MS modes on the facility TOF, TOF/TOF, triple quadrupoles, Q-TOF or hybrid linear ion trap ICR instrument (LTQ-FT). A suite of separation interfaces are supported including GC and HPLC in the performance regimes of analytical micro, capillary, nano and ultrahigh pressure. Laboratory personnel are available at all times to discuss the capabilities of the laboratory, to offer advice on experimental design and to discuss the interpretation of data. Investigators are routinely trained to use primary data presentation software to interrogate their experiments. The APL maintains a collection of software tools for the analysis of proteomics experiments. The lab has experience with a wide variety of sample types including, providing support to synthetic groups, characterizing medicinal compounds and natural products, and characterizing proteins and protein modifications. The services of the laboratory are typically used by the School of Pharmacy and the Departments of Medicinal Chemistry and Chemistry, but any investigator considering mass spectrometry for problem solving is encouraged to contact the Director.